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Humulene

HYOO-muh-leen /ˈhjuːmjʊliːn/

Found in hops and cannabis. Humulene has anti-inflammatory properties and may suppress appetite through IL-8 pathway modulation.

Concentration
0.03-0.4%
Strains Found
15+

Aroma Profile

Hoppy, woody, earthy

Flavor Notes

Subtle earthy, herbal

Also Found In

Hops Sage Ginger Cannabis

Primary Effects

Appetite suppressant
Anti-inflammatory
Antibacterial

How It Works

  • Binds moderately to CB1, strongly to CB2
  • Increases IL-8 levels
  • Reduces meal size (not frequency)
  • Peaks in blood within 30 min, clears in ~2 hours

Clinical Evidence

Research shows humulene increases IL-8 levels, which in animal studies directly reduces appetite by decreasing meal size without affecting meal frequency. Peaks in blood within 30 min, clears within ~2 hours.

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